The Toxicity of Caffein: An experimental study on different species of animals

The study reports controlled laboratory experiments that measure physiological effects, toxicity, and lethal responses to caffein in multiple mammalian species. After a historical review it presents acute and chronic exposure trials, with detailed protocols for oral, subcutaneous, intraperitoneal, intramuscular, and intravenous administration. Separate sections document clinical observations, autopsy findings, and dose-response differences in rabbits, guinea pigs, cats, and dogs. Results are analyzed in light of comparative metabolism, and the report concludes with a discussion and concise summary of interspecies variation in sensitivity and elimination of the alkaloid.